杜杰，男，教授，博士生导师，海南省拔尖人才，热带海洋先进功能材料团队负责人，中国化学学会高级会员，日本高分子学会会员。从事的研究方向包括：DNA纳米技术，生物传感器，柔性可穿戴器件与脑机接口，锂离子电池用凝胶电解质等，承担国家级、省部级项目十余项。担任Biosensors, Polymers 等期刊客座编辑。以第一作者、通讯作者发表英文SCI论文80余篇，出版专著2部。

Email：dujie@hainanu.edu.cn

ResearchGate ID: https://www.researchgate.net/profile/Jie-Du-5

教育背景

1999-09 至 2003-07, 华中科技大学, 应用化学, 本科

2003-09 至 2008-01, 大连理工大学, 高分子材料与工程, 硕博连读

工作经历

2008-04 至 2010-08, 日本九州大学，博士后（JSPS外国人特别研究员）

2010-09 至 2019-02, 海南大学, 材料与化工学院, 教授

2019-03 至 今, 海南大学, 开云kaiyun官方入口, 教授

研究方向

DNA纳米技术，生物传感器，柔性可穿戴器件与脑机接口，锂离子电池用凝胶电解质

科研简介

（1）基于梳型阳离子共聚物的DNA构型转换与精确快速自组装

设计带有亲水性多糖支链、主链为聚阳离子的梳型共聚物，能够在较低的DNA浓度和较少的粘性末端条件下加速DNA杂化及链交换反应，同时提高DNA多级结构的稳定性，从而实现DNA纳米结构的精确、快速及可控组装。基于此，在梳型阳离子共聚物辅助作用下，我们构建了一系列的DNA结构单元、纳米机器、DNA水凝胶，以及DNA折纸结构组装体。

（2）基于DNA组装体的生物传感器的构建

DNA生物传感器具有灵敏度高、特异性好、操作简便等特点，被广泛应用于目标分子的检测。因此，高灵敏性、低成本的DNA生物传感器的构建成为近年来的研究热点。我们围绕着背景信号抑制策略、信号放大策略构建了一系列的荧光标记、非荧光标记、无生物酶、多功能DNA光学及电化学生物传感器，将其应用于血管内皮生长因子(VEGF)、血小板源生长因子(PDGF-BB)、胰岛素、microRNA为代表的生物分子检测，并对其检测性能进行了系统的研究。

（3）柔性可穿戴器件与脑机接口的构建

设计了一种具有自愈、自粘、抗菌和传感稳定性的自供电生物水凝胶伤口敷料，该敷料在实时监测身体活动和药物释放方面表现出优异的性能。开发了一种多功能不对称 Janus水凝胶电子皮肤，通过氢键和金属配体配位制备的水凝胶在不添加额外交联剂的情况下表现出显著的韧性和拉伸性，显示出良好的自愈效率和优异的生物相容性。这种水凝胶在空气和水下都表现出独特的不对称粘附性能，可以监测运动、肌电和脑电信号。还可以准确识别手势，实时控制辅助机械手臂。这种水凝胶在健康监测、康复治疗和人机交互方面具有巨大的潜力。

（4）高分子膜材料和聚合物凝胶电解质在高性能锂离子电池中的应用

开发了一系列高性能的高分子膜材料和聚合物电解质，有效抑制锂枝晶生长，提高锂离子电池的综合性能。具体包括：优化高分子膜材料的性能，通过分子结构设计提高膜材料的离子电导率、机械强度和化学稳定性，以满足电池对环保和可持续发展的要求；研究聚合物电解质抑制锂枝晶生长的机理，建立更加完善的理论模型，为开发高效聚合物电解质提供理论指导；通过改进合成方法，优化单离子聚合物电解质膜的结构和性能，提高离子电导率。加强对聚合物电解质膜与电极界面兼容性的研究，降低界面电阻，提高电池的充放电效率；开展高性能锂离子电池的系统集成研究，综合考虑电池的能量密度、功率密度、循环寿命等因素，优化电池的设计与产业化应用。

代表性成果

[1] Zilu Xue, Jie Du. Recent progresses on multifunctional tactile sensors for electronic skins and human-machine interaction applications. Sensors and Actuators Reports 2026, 11, 100459.

[2] Jinran Li, Zhenrui Du, Jie Du. Research progress on templated methods for perovskite nanomaterials in solar energy conversion. Molecules 2026, 31, 2586.

[3] Haiyu Li, Hui Zhang, Xinxin Liu, et al. Chinese Nian Gao Inspired Textured Janus Hydrogel for Body Signal Sensing and Human Machine Interaction. Adv. Sci. 2025, 12, e09573.

[4] Zhenrui Du, Na Wang, Jie Du. Recent Progress in Cellulose-Based Conductive Hydrogels. Polymers 2025, 17, 1089.

[5] Haiyu Li, Hui Zhang, Yangrui Peng, et al. Rapid Synthesis of Functions- Integrated Hydrogel as a Self-Powered Wound Dressing for Real-Time Drug Release and Health Monitoring. Adv. Healthcare Mater. 2024, 13, 2401704.

[6] Yazhen Liao, Xiaoxue Yin, Wenqian Liu, et al. Chaperone Copolymer-Assisted Catalytic Hairpin Assembly for Highly Sensitive Detection of Adenosine. Polymers 2024, 16, 2179.

[7] Xiaoxue Yin, Yazhen Liao, Feiyu Li, et al. Enzyme-Assisted Fluorescence Biosensor Based on Circular Single-Stranded DNA Without Group Modification for MicroRNA Detection. Biosensors 2024, 14, 527.

[8] Yubing Chen , Kunyao He , Xudong Hao, et al. Boron-containing cross-linker assisted single-ion conducting polymer electrolytes for high-performance and dendrite-free Li-metal batteries. Polymer 2024, 311, 127576.

[9] Yazhen Liao, Yuxing Yang, Yang Qing, et al. Enzyme-Free Signal Amplification Strategy via Chaperone Copolymer-Accelerated Hybridization for Highly Sensitive Detection of Adenosine. Chemosensors 2023, 11, 522.

[10] Yang Qing, Haobin Fang, Yuxing Yang, et al. Enzyme-Assisted Amplification and Copper Nanocluster Fluorescence Signal-Based Method for miRNA-122 Detection. Biosensors 2023, 13, 854.

[11] Yuxing Yang, Yazhen Liao, Yang Qing, et al. Electrochemical DNA Biosensors with Dual-Signal Amplifification Strategy for Highly Sensitive HPV 16 Detection. Sensors 2023, 23, 7380.

[12] Chenxin Fang, Yuxing Yang, Shuhao Zou, et al. Signal-On Fluorescence Biosensor for Highly Sensitive Detection of miRNA-21 Based on DNAzyme Assisted Double-Hairpin Molecular Beacon. Biosensors 2022, 12, 276.

[13] Ping Ouyang, Yang Qing, Shuhao Zou, et al. Sensitive detection of miR-122 via toehold-promoted strand displacement reaction and enzyme-assisted cycle amplification. Biochemical Engineering Journal 2022, 186, 108576.

[14] Yang Qing, Yuxing Yang, Ping Ouyang, et al. Gold Nanoparticle-Based Enzyme-Assisted Cyclic Amplification for the Highly-Sensitive Detection of miRNA-21. Biosensors 2022, 12, 724.

[15] Jialun Han, Chenxin Fang, Ping Ouyang, et al. Chaperone Copolymer Assisted G-Quadruplex-Based Signal Amplifification Assay for Highly Sensitive Detection of VEGF. Biosensors 2022, 12, 262.

[16] Yuxing Yang, Yang Qing, Xudong Hao, et al. APTES-Modifified Remote Self-Assembled DNA-Based Electrochemical Biosensor for Human Papillomavirus DNA Detection. Biosensors 2022, 12, 449.

[17] Ping Ouyang, Chenxin Fang, Jialun Han, et al. A DNA Electrochemical Sensor via Terminal Protection of Small-Molecule-Linked DNA for Highly Sensitive Protein Detection. Biosensors 2021, 11, 451.

[18] Chenxin Fang, Ping Ouyang, Yuxing Yang, et al. MiRNA Detection Using a Rolling Circle Amplification and RNA-Cutting Allosteric Deoxyribozyme Dual Signal Amplification Strategy. Biosensors 2021, 11, 222.

[19] Yubing Chen , Guangping Chen , Chaoqun Niu, et al. Ether-containing polycarbonate-based solid polymer electrolytes for Dendrite-Free Lithium metal batteries. Polymer 2021, 223, 123695.

[20] Lingzhu Zhao, Jingchuan Fu, Zhi Du, et al. High-strength and flflexible cellulose/PEG based gel polymer electrolyte with high performance for lithium ion batteries. Journal of Membrane Science 2020, 593, 117428.

[21] Guangping Chen, Chaoqun Niu, Xiaoxue Liao, et al. Boron-containing single-ion conducting polymer electrolyte for dendrite free lithium metal batteries. Solid State Ionics 2020, 349, 115309.

[22] Wenyan Shang, Yubing Chen, Jialun Han, et al. Dendrite-free Li Anode Enabled by a Metal−Organic FrameworkModifified Solid Polymer Electrolyte for High-Performance Lithium Metal Batteries. ACS Appl. Energy Mater. 2020, 3, 12351-12359.

[23] Wenyan Shang, Chaoqun Niu, Guangping Chen, et al. Anion-inhibited solid framework polymer electrolyte for dendrite-free lithium metal batteries. Electrochimica Acta 2020, 338, 135902.